| DATE | OPPONENT | RESULT | RECORD |
| 9/3/21 | CENTRAL CATHOLIC | W 3-0 | 1-0 |
| 9/4/21 | FRANKLIN REGIONAL | W 3-1 | 2-0 |
| 9/7/21 | BALDWIN * | W 6-1 | 3-0, (1-0) |
| 9/9/21 | BRASHEAR * | W 2-0 | 4-0, (2-0) |
| 9/14/21 | at Bethel Park * | W 5-2 | 5-0, (3-0) |
| 9/18/21 | MT. LEBANON * | W 4-0 | 6-0, (4-0) |
| 9/21/21 | at Upper St. Clair * | W 2-1 | 7-0, (5-0) |
| 9/23/21 | CANON-MCMILLAN * | L 3-2 | 7-1, (5-1) |
| 9/28/21 | BALDWIN * | W 7-0 | 8-1, (6-1) |
| 9/30/21 | at Brashear * | W 3-0 | 9-1, (7-1) |
| 10/2/21 | BETHEL PARK * | W 5-0 | 10-1, (8-1) |
| 10/4/21 | QUAKER VALLEY | W 3-2 | 11-1 |
| 10/7/21 | at Mt. Lebanon * | T 2-2 | 11-1-1, (8-1-1) |
| 10/12/21 | UPPER ST. CLAIR * | W 7-1 | 12-1-1, (9-1-1) |
| 10/14/21 | at Canon-McMillan * | W 4-1 | 13-1-1, (10-1-1) |
| 10/19/21 | PINE-RICHLAND | W 4-1 | 14-1-1 |
| 10/30/21 | BUTLER ** | W 4-2 | 15-1-1 |
| 11/2/21 | North Allegheny **
at West Allegheny | W 4-1 | 16-1-1 |
| 11/6/21 | WPIAL CHAMPIONSHIP
Seneca Valley **
at Highmark Stadium | L 3-1 | 16-2-1 |
| 11/9/21 | PIAA FIRST ROUND
at State College ** | W 3-1 | 17-2-1 |
| 11/13/21 | PIAA QUARTERFINALS
Central Dauphin **
at Hollidaysburg | W 2-0 | 18-2-1 |
| 11/16/21 | PIAA SEMIFINALS
Seneca Valley **
at North Allegheny | L 2-1 | 18-3-1 |